The Difference between Targeted Drug Therapies and Targeted-Drug Therapies

Biocomputing drug repurposing toward targeted therapies

inhibition of the oncogenic activation of signalling pathways represents the main goal of drug discovery in oncology. Selective inhibitors of oncogenes such as mutated kinases and phosphatases have been identified mainly through traditional small molecule drug screenings aimed at identifying inhibitors of catalytic activity. However, ever-increasing failure rates, high costs, unsatisfactory saf...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Emerging Drug Therapies for Heart Failure

Heart failure is associated with high morbidity and mortality and is proving to be an economic burden in developing countries. A number of therapeutic agents are presently employed in heart failure; but they are not sufficient to control symptoms of heart failure. Moreover, the prevalence of chronic heart failure is progressively increasing and thus there is a continuing need to develop effecti...

B cell targeted therapies

Although the precise pathogenesis of rheumatoid arthritis (RA) remains unclear, many cell populations, including monocytes, macrophages, endothelial cells, fibroblasts and B cells, participate in the inflammatory process. Ongoing research continues to evaluate the critical roles played by B cells in sustaining the chronic inflammatory process of RA. These findings have contributed to the develo...